ATP synthase subunit c
Also known as: Rv1305, atpE
Function
F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
Classification
- Family (Pfam)
- PF00137 ATP-synt_C
- InterPro
- ATP_synth_csu_bac/chlpt, ATP_synth_F0_csu, ATP_synth_F0_csu_DDCD_BS, ATP_synth_F0_csu_sf, ATPase_proteolipid_c-like_dom, F/V-ATP_Csub_sf
- Functional cluster
- Respiratory Chain & ATP Synthase Subunits
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 7
- GO:0005886 plasma membrane
- GO:0045259 proton-transporting ATP synthase complex
- GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
- GO:0008289 lipid binding
- GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
- GO:0015986 proton motive force-driven ATP synthesis
- GO:1902600 proton transmembrane transport
Drugs targeting this protein · 1
- BEDAQUILINE FUMARATE inhibitor
Related proteins · sequence + function similarity
- ATP synthase subunit c 1.00
- ATP synthase subunit c 1.00
- ATP synthase subunit c 1.00
- ATP synthase subunit c 1.00
- ATP synthase subunit c 1.00
- ATP synthase subunit c 1.00
- ATP synthase subunit c 0.99
- ATP synthase subunit c 0.99
- ATP synthase subunit c 0.99
- ATP synthase subunit c 0.99
- ATP synthase subunit c 0.99
- ATP synthase subunit c 0.99
Literature · 2 cited papers
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