Dihydrofolate reductase
Also known as: Rv2763c, dfrA, folA
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Classification
- Family (Pfam)
- PF00186 DHFR_1
- InterPro
- DHFR, DHFR-like_dom_sf, DHFR_CS, DHFR_dom
- Functional cluster
- Cell-Envelope & Cofactor Biosynthesis Enzymes
Experimental structures · PDB · 59
- 1DF7 X-ray 1.70A
- 1DG5 X-ray 2.00A
- 1DG7 X-ray 1.80A
- 1DG8 X-ray 2.00A
- 2CIG X-ray 1.90A
- 4KL9 X-ray 1.39A
- 4KLX X-ray 1.23A
- 4KM0 X-ray 1.30A
- 4KM2 X-ray 1.40A
- 4KNE X-ray 2.00A
- 4M2X X-ray 2.26A
- 5JA3 X-ray 1.81A
- … and 47 more
A predicted model is available from AlphaFold.
Gene Ontology · 8
Drugs targeting this protein · 3
- AMINOSALICYLIC ACID inhibitor
- AMINOSALICYLATE POTASSIUM inhibitor
- AMINOSALICYLATE SODIUM inhibitor
Related proteins · sequence + function similarity
- Dihydrofolate reductase 1.00
- Dihydrofolate reductase 0.92
- Dihydrofolate reductase type A13 0.70
- Dihydromethanopterin reductase 0.66
- Dihydrofolate reductase type 7 0.64
- Dihydrofolate reductase 0.64
- Dihydrofolate reductase type 5 0.63
- Dihydrofolate reductase 0.62
- Dihydrofolate reductase 0.61
- Dihydrofolate reductase 0.61
- Dihydrofolate reductase 0.61
- Dihydrofolate reductase type 15 0.61
Literature · 4 cited papers
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
- Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid. Nat. Struct. Mol. Biol. · 2006
- Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J. Mol. Biol. · 2000
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998
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