Probable arabinosyltransferase A

Function

Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.

Classification

Family (Pfam)

PF14896 Arabino_trans_C, PF17689 Arabino_trans_N, PF04602 Arabinose_trans

InterPro

Arabino_trans_C, Arabino_trans_C_2, Arabino_trans_central, Arabino_trans_N, EmbABC_dom1

Functional cluster

Respiratory Chain & ATP Synthase Subunits

Experimental structures · PDB · 1

• 7BVF EM 2.97A

A predicted model is available from AlphaFold.

Gene Ontology · 6

• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0052636 arabinosyltransferase activity
• GO:0071766 Actinobacterium-type cell wall biogenesis
• GO:0071555 cell wall organization
• GO:0046677 response to antibiotic

Drugs targeting this protein · 1

• ETHAMBUTOL HYDROCHLORIDE inhibitor

Related proteins · sequence + function similarity

• Probable arabinosyltransferase A 1.00
• Probable arabinosyltransferase A 0.99
• Probable arabinosyltransferase C 0.98
• Probable arabinosyltransferase C 0.98
• Probable arabinosyltransferase C 0.97
• Probable arabinosyltransferase C 0.97
• Probable arabinosyltransferase A 0.97
• Probable arabinosyltransferase B 0.97
• Probable arabinosyltransferase A 0.96
• Probable arabinosyltransferase B 0.96
• Probable arabinosyltransferase B 0.96
• Probable arabinosyltransferase B 0.96

Co-cited proteins · studied together in the literature

• Probable arabinosyltransferase B 3 shared papers
• Probable arabinosyltransferase C 3 shared papers
• Probable arabinosyltransferase A 1 shared papers
• Probable arabinosyltransferase B 1 shared papers
• Probable arabinosyltransferase C 1 shared papers
• Transcriptional regulatory protein EmbR 1 shared papers
• Serine/threonine-protein kinase PknH 1 shared papers

Literature · 6 cited papers

• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
• Transcriptional control of the mycobacterial embCAB operon by PknH through a regulatory protein, EmbR, in vivo. J. Bacteriol. · 2006
• Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. · 2000
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998
• The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nat. Med. · 1997