Large ribosomal subunit protein bL12

Function

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.

Classification

Family (Pfam)

PF00542 Ribosomal_L12, PF16320 Ribosomal_L12_N

InterPro

Ribosomal_bL12, Ribosomal_bL12_C, Ribosomal_bL12_C/ClpS-like, Ribosomal_bL12_oligo, Ribosomal_bL12_oligo_N_sf

Functional cluster

Ribosomal Protein L12 & Acyl Carriers

Gene Ontology · 8

• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0009274 peptidoglycan-based cell wall
• GO:0005886 plasma membrane
• GO:0003729 mRNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0006412 translation

Drugs targeting this protein · 4

• CAPREOMYCIN SULFATE inhibitor
• SUTEZOLID inhibitor
• VIOMYCIN SULFATE inhibitor
• PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein bL12 1.00
• Large ribosomal subunit protein bL12 1.00
• Large ribosomal subunit protein bL12 0.99
• Large ribosomal subunit protein bL12 0.99
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98
• Large ribosomal subunit protein bL12 0.98

Literature · 4 cited papers

• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998