Large ribosomal subunit protein uL15

Function

Binds to the 23S rRNA.

Classification

Family (Pfam)

PF00828 Ribosomal_L27A

InterPro

Ribosomal_uL15, Ribosomal_uL15/eL18, Ribosomal_uL15/eL18_sf, Ribosomal_uL15_bact, Ribosomal_uL15_CS

Functional cluster

Large Ribosomal Subunit Proteins

Experimental structures · PDB · 11

• 5V7Q EM 3.70A
• 5V93 EM 4.00A
• 7KGB EM 2.70A
• 7MSC EM 2.97A
• 7MSH EM 3.23A
• 7MSM EM 2.79A
• 7MSZ EM 3.10A
• 7MT2 EM 2.76A
• 7MT3 EM 2.80A
• 7MT7 EM 2.71A
• 7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 5

• GO:0022625 cytosolic large ribosomal subunit
• GO:0005886 plasma membrane
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0006412 translation

Drugs targeting this protein · 4

• CAPREOMYCIN SULFATE inhibitor
• SUTEZOLID inhibitor
• VIOMYCIN SULFATE inhibitor
• PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 1.00
• Large ribosomal subunit protein uL15 0.98
• Large ribosomal subunit protein uL15 0.98
• Large ribosomal subunit protein uL15 0.97
• Large ribosomal subunit protein uL15 0.97
• Large ribosomal subunit protein uL15 0.96
• Large ribosomal subunit protein uL15 0.96
• Large ribosomal subunit protein uL15 0.95
• Large ribosomal subunit protein uL15 0.95

Literature · 4 cited papers

• Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998