Large ribosomal subunit protein uL1
Also known as: Rv0641, rplA
Function
Binds directly to 23S rRNA. The L1 stalk is very mobile in the ribosome, and is involved in E site tRNA release.
Classification
- Family (Pfam)
- PF00687 Ribosomal_L1
- InterPro
- Ribosom_uL1_bact, Ribosomal_uL1, Ribosomal_uL1-like, Ribosomal_uL1/biogenesis, Ribosomal_uL1_3-a/b-sand, Ribosomal_uL1_CS
- Functional cluster
- Ribosomal S11 & RuvC Resolvases
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 10
- GO:0005829 cytosol
- GO:0022625 cytosolic large ribosomal subunit
- GO:0009274 peptidoglycan-based cell wall
- GO:0005886 plasma membrane
- GO:0003729 mRNA binding
- GO:0019843 rRNA binding
- GO:0003735 structural constituent of ribosome
- GO:0000049 tRNA binding
- GO:0006417 regulation of translation
- GO:0006412 translation
Drugs targeting this protein · 4
- CAPREOMYCIN SULFATE inhibitor
- SUTEZOLID inhibitor
- VIOMYCIN SULFATE inhibitor
- PYRAZINAMIDE inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL1 1.00
- Large ribosomal subunit protein uL1 1.00
- Large ribosomal subunit protein uL1 1.00
- Large ribosomal subunit protein uL1 1.00
- Large ribosomal subunit protein uL1 0.98
- Large ribosomal subunit protein uL1 0.98
- Large ribosomal subunit protein uL1 0.97
- Large ribosomal subunit protein uL1 0.97
- Large ribosomal subunit protein uL1 0.97
- Large ribosomal subunit protein uL1 0.97
- Large ribosomal subunit protein uL1 0.96
- Large ribosomal subunit protein uL1 0.95
Literature · 4 cited papers
- Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
- Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998
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