Large ribosomal subunit protein uL22

Function

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

Classification

Family (Pfam)

PF00237 Ribosomal_L22

InterPro

Ribosomal_uL22, Ribosomal_uL22_bac/chlpt-type, Ribosomal_uL22_bact_org, Ribosomal_uL22_CS, Ribosomal_uL22_sf

Functional cluster

Ribosomal Proteins (S5/S18, L17/L22)

Experimental structures · PDB · 11

• 5V7Q EM 3.70A
• 5V93 EM 4.00A
• 7KGB EM 2.70A
• 7MSC EM 2.97A
• 7MSH EM 3.23A
• 7MSM EM 2.79A
• 7MSZ EM 3.10A
• 7MT2 EM 2.76A
• 7MT3 EM 2.80A
• 7MT7 EM 2.71A
• 7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 5

• GO:0022625 cytosolic large ribosomal subunit
• GO:0009274 peptidoglycan-based cell wall
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0006412 translation

Drugs targeting this protein · 4

• CAPREOMYCIN SULFATE inhibitor
• SUTEZOLID inhibitor
• VIOMYCIN SULFATE inhibitor
• PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 1.00
• Large ribosomal subunit protein uL22 0.98
• Large ribosomal subunit protein uL22 0.98
• Large ribosomal subunit protein uL22 0.95
• Large ribosomal subunit protein uL22 0.95
• Large ribosomal subunit protein uL22 0.92
• Large ribosomal subunit protein uL22 0.92
• Large ribosomal subunit protein uL22 0.88
• Large ribosomal subunit protein uL22 0.87

Literature · 5 cited papers

• Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998