Large ribosomal subunit protein uL23

UniProt P9WHB9 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv0703, rplW

Also known as: Rv0703, rplW

Function

One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.

Classification

Family (Pfam): PF00276 Ribosomal_L23
InterPro: Nucleotide-bd_a/b_plait_sf, Ribosomal_uL23-like, Ribosomal_uL23/eL15/eS24_sf, Ribosomal_uL23_CS
Functional cluster: Small/Large Ribosomal Subunit Proteins

Experimental structures · PDB · 11

5V7Q EM 3.70A
5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 6

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 5 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

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