Large ribosomal subunit protein uL24

UniProt P9WHB7 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv0715, rplX

Also known as: Rv0715, rplX

Function

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.

Classification

Family (Pfam): PF00467 KOW, PF17136 ribosomal_L24
InterPro: KOW, Rib_uL2_dom2, Ribosomal_uL24, Ribosomal_uL24_C, Ribosomal_uL24_CS, Ribosomal_uL24_KOW, Translation_prot_SH3-like_sf
Functional cluster: Ribosomal Proteins (S16/S17/L24/L30)

Experimental structures · PDB · 11

5V7Q EM 3.70A
5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 5

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 4 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

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