Large ribosomal subunit protein bL25

UniProt P9WHB5 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv1015c, ctc, rplY

Also known as: Rv1015c, ctc, rplY

Function

This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

Classification

Family (Pfam): PF01386 Ribosomal_L25p, PF14693 Ribosomal_TL5_C
InterPro: Rbsml_bL25/Gln-tRNA_synth_N, Ribosomal_bL25/Gln-tRNA_synth, Ribosomal_bL25_b-dom, Ribosomal_bL25_C, Ribosomal_bL25_long, Ribosomal_L25_dom, Ribosomal_uL5_bact
Functional cluster: Ribosomal Proteins & Trigger Factor

Experimental structures · PDB · 11

5V7Q EM 3.70A
5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 5

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 4 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

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