Large ribosomal subunit protein uL2

UniProt P9WHA5 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv0704, rplB

Also known as: Rv0704, rplB

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam): PF03947 Ribosomal_L2_C, PF00181 Ribosomal_L2_N
InterPro: NA-bd_OB-fold, Rib_uL2_dom2, Ribosomal_uL2, Ribosomal_uL2_bact_org, Ribosomal_uL2_C, Ribosomal_uL2_CS, Ribosomal_uL2_dom3, Ribosomal_uL2_RNA-bd_dom, Translation_prot_SH3-like_sf
Functional cluster: Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 10

5V7Q EM 3.70A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 4 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

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