Large ribosomal subunit protein uL4
Also known as: Rv0702, rplD
Function
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
Classification
- Family (Pfam)
- PF00573 Ribosomal_L4
- InterPro
- Ribosomal_uL4, Ribosomal_uL4-like, Ribosomal_uL4_dom_sf
- Functional cluster
- Large-Subunit Ribosomal Proteins (L4/L20/L35)
Experimental structures · PDB · 11
- 5V7Q EM 3.70A
- 5V93 EM 4.00A
- 7KGB EM 2.70A
- 7MSC EM 2.97A
- 7MSH EM 3.23A
- 7MSM EM 2.79A
- 7MSZ EM 3.10A
- 7MT2 EM 2.76A
- 7MT3 EM 2.80A
- 7MT7 EM 2.71A
- 7SFR EM 2.60A
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 4
- CAPREOMYCIN SULFATE inhibitor
- SUTEZOLID inhibitor
- VIOMYCIN SULFATE inhibitor
- PYRAZINAMIDE inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 1.00
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.98
- Large ribosomal subunit protein uL4 0.97
Literature · 4 cited papers
- Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
- Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
- Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998
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