Large ribosomal subunit protein uL5

Function

This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

Classification

Family (Pfam)

PF00281 Ribosomal_L5, PF00673 Ribosomal_L5_C

InterPro

Ribosomal_uL5, Ribosomal_uL5_bact, Ribosomal_uL5_C, Ribosomal_uL5_dom_sf, Ribosomal_uL5_N

Functional cluster

Large Ribosomal Subunit Proteins

Experimental structures · PDB · 11

• 5V7Q EM 3.70A
• 5V93 EM 4.00A
• 7KGB EM 2.70A
• 7MSC EM 2.97A
• 7MSH EM 3.23A
• 7MSM EM 2.79A
• 7MSZ EM 3.10A
• 7MT2 EM 2.76A
• 7MT3 EM 2.80A
• 7MT7 EM 2.71A
• 7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0022625 cytosolic large ribosomal subunit
• GO:0005886 plasma membrane
• GO:0003723 RNA binding
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0006412 translation

Drugs targeting this protein · 4

• CAPREOMYCIN SULFATE inhibitor
• SUTEZOLID inhibitor
• VIOMYCIN SULFATE inhibitor
• PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 1.00
• Large ribosomal subunit protein uL5 0.98
• Large ribosomal subunit protein uL5 0.98
• Large ribosomal subunit protein uL5 0.97
• Large ribosomal subunit protein uL5 0.96
• Large ribosomal subunit protein uL5 0.96
• Large ribosomal subunit protein uL5 0.96
• Large ribosomal subunit protein uL5 0.96

Literature · 4 cited papers

• Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
• Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
• Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
• Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998