Large ribosomal subunit protein uL6

UniProt P9WH81 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv0719, rplF

Also known as: Rv0719, rplF

Function

This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

Classification

Family (Pfam): PF00347 Ribosomal_L6
InterPro: Ribosomal_uL6-like, Ribosomal_uL6-like_a/b-dom_sf, Ribosomal_uL6_a/b-dom, Ribosomal_uL6_bact, Ribosomal_uL6_CS
Functional cluster: Globins & Ribosomal Protein L6

Experimental structures · PDB · 11

5V7Q EM 3.70A
5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 6

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 4 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

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