Small ribosomal subunit protein uS15

UniProt P9WH55 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv2785c, rpsO

Also known as: Rv2785c, rpsO

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.

Classification

Family (Pfam): PF00312 Ribosomal_S15
InterPro: Ribosomal_uS15, Ribosomal_uS15_bact, uS15_NS1_RNA-bd_sf
Functional cluster: Ribosomal Proteins & ATP Synthase Subunits

Experimental structures · PDB · 10

5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 5

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 4 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.