lmmol · Proteins

Small ribosomal subunit protein bS1

UniProt P9WH43 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv1630, rpsA

Also known as: Rv1630, rpsA

Function

Binds mRNA, facilitating recognition of most mRNAs by the 30S ribosomal subunit during translation initiation (By similarity). Probably plays a role in trans-translation; binds tmRNA (the product of the ssrA gene). In trans-translation Ala-aminoacylated transfer-messenger RNA (tmRNA, product of the ssrA gene; the 2 termini fold to resemble tRNA(Ala) while it encodes a short internal open reading frame (the tag peptide)) acts like a tRNA, entering the A-site of the ribosome and displacing the stalled mRNA (which is subsequently degraded). The ribosome then switches to translate the ORF on the tmRNA, the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and thus targeted for degradation (By similarity).

Classification

Family (Pfam)
PF00575 S1
InterPro
NA-bd_OB-fold, Ribos_protein_bS1-like, Ribosomal_protein_S1-like, S1_domain
Functional cluster
ABC Transporter ATPases & DnaJ Chaperones

Experimental structures · PDB · 3

A predicted model is available from AlphaFold.

Gene Ontology · 8

Drugs targeting this protein · 4

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 4 cited papers

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