Small ribosomal subunit protein uS3

UniProt P9WH37 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv0707, rpsC

Also known as: Rv0707, rpsC

Function

Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.

Classification

Family (Pfam): PF07650 KH_2, PF00189 Ribosomal_S3_C
InterPro: KH_dom, KH_dom-like_a/b, KH_dom_type_2, KH_sf_prok-type, Ribosomal_S3_C_sf, Ribosomal_uS3, Ribosomal_uS3_bact, Ribosomal_uS3_C, Ribosomal_uS3_CS
Functional cluster: AAA+ ATPases & Chaperones

Experimental structures · PDB · 10

5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 4 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.