Small ribosomal subunit protein uS4

UniProt P9WH35 Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Gene Rv3458c, rpsD

Also known as: Rv3458c, rpsD

Function

One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.

Classification

Family (Pfam): PF00163 Ribosomal_S4, PF01479 S4
InterPro: Ribosomal_uS4, Ribosomal_uS4_bact, Ribosomal_uS4_CS, Ribosomal_uS4_N, S4_RNA-bd, S4_RNA-bd_sf
Functional cluster: Photosystem Reaction-Center Proteins

Experimental structures · PDB · 10

5V93 EM 4.00A
7KGB EM 2.70A
7MSC EM 2.97A
7MSH EM 3.23A
7MSM EM 2.79A
7MSZ EM 3.10A
7MT2 EM 2.76A
7MT3 EM 2.80A
7MT7 EM 2.71A
7SFR EM 2.60A

A predicted model is available from AlphaFold.

Gene Ontology · 8

Drugs targeting this protein · 4

CAPREOMYCIN SULFATE inhibitor
SUTEZOLID inhibitor
VIOMYCIN SULFATE inhibitor
PYRAZINAMIDE inhibitor

Related proteins · sequence + function similarity

Literature · 5 cited papers

Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis. Nat. Commun. · 2022
Structural insights into species-specific features of the ribosome from the human pathogen Mycobacterium tuberculosis. Nucleic Acids Res. · 2017
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol. Cell. Proteomics · 2011
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst. Biol. · 2008
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature · 1998

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