Large ribosomal subunit protein eL19

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01280 Ribosomal_L19e, PF25476 Ribosomal_L19e_C

InterPro

60S_ribosomal_eL19_sf, Ribosomal_eL19, Ribosomal_eL19_CS, Ribosomal_eL19_dom, Ribosomal_eL19_dom1, Ribosomal_eL19_euk, Ribosomal_L19e, Ribosomal_L19e_C

Functional cluster

Large-Subunit Ribosomal Proteins (L4/L20/L35)

Experimental structures · PDB · 149

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• … and 137 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 1.00
• Large ribosomal subunit protein eL19 0.99
• Large ribosomal subunit protein eL19 0.99
• Large ribosomal subunit protein eL19 0.99
• Large ribosomal subunit protein eL19 0.95
• Large ribosomal subunit protein eL19B 0.95

Co-cited proteins · studied together in the literature

• Elongation factor 1-gamma 1 shared papers

Literature · 16 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc. Natl. Acad. Sci. U.S.A. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• … and 4 more in the literature graph