Large ribosomal subunit protein eL42

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00935 Ribosomal_L44

InterPro

Ribosomal_eL44, Ribosomal_LSU_eL42, Ribosomal_zn-bd

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 120

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 108 more

A predicted model is available from AlphaFold.

Gene Ontology · 12

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005783 endoplasmic reticulum
• GO:0005840 ribosome
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL42 1.00
• Large ribosomal subunit protein eL42 1.00
• Large ribosomal subunit protein eL42 1.00
• Large ribosomal subunit protein eL42 1.00
• Ribosomal protein eL42-like 1.00
• Large ribosomal subunit protein eL42 1.00
• Large ribosomal subunit protein eL42 0.99
• Large ribosomal subunit protein eL42 0.99
• Large ribosomal subunit protein eL42 0.99
• Large ribosomal subunit protein eL42 0.97
• Large ribosomal subunit protein eL42 0.94
• Large ribosomal subunit protein eL42 0.94

Co-cited proteins · studied together in the literature

• Heterogeneous nuclear ribonucleoprotein H2 1 shared papers

Literature · 6 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• The DNA sequence of the human X chromosome. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Genome Res. · 1997