Hemoglobin subunit alpha

UniProt P69905 Organism Homo sapiens Gene HBA1, HBA2

Also known as: HBA1, HBA2

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Classification

Family (Pfam): PF00042 Globin
InterPro: Globin, Globin-like_sf, Globin/Proto, Hemoglobin_a-typ, Hemoglobin_oxygen_transport, Hemoglobin_pi
Functional cluster: Globins & Ribosomal Protein L6

Experimental structures · PDB · 347

1A00 X-ray 2.00A
1A01 X-ray 1.80A
1A0U X-ray 2.14A
1A0Z X-ray 2.00A
1A3N X-ray 1.80A
1A3O X-ray 1.80A
1A9W X-ray 2.90A
1ABW X-ray 2.00A
1ABY X-ray 2.60A
1AJ9 X-ray 2.20A
1B86 X-ray 2.50A
1BAB X-ray 1.50A
… and 335 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

Disease associations

Heinz body anemia MONDO:0007705
OMIM:141800 RAW:OMIM_141800
alpha thalassemia spectrum MONDO:0011399
hemoglobin H disease MONDO:0013512

Drugs targeting this protein · 2

EFAPROXIRAL negative modulator
VOXELOTOR positive modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Hemoglobin subunit beta 7 shared papers
Hemoglobin subunit epsilon 1 shared papers
Iron-regulated surface determinant protein B 1 shared papers
Aspartic protease 2 1 shared papers
Hemoglobin subunit theta-1 1 shared papers
Hemoglobin subunit mu 1 shared papers
U11/U12 small nuclear ribonucleoprotein 25 kDa protein 1 shared papers
Neurolysin, mitochondrial 1 shared papers
Thimet oligopeptidase 1 shared papers
Hemoglobin subunit alpha-1/2 1 shared papers
Angiotensin-converting enzyme 1 shared papers
Inactive rhomboid protein 1 1 shared papers

Literature · 116 cited papers

Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin. J. Biol. Chem. · 2018
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc. Natl. Acad. Sci. U.S.A. · 2007
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. Science · 2006
A novel mutation of the alpha2-globin causing alpha(+)-thalassemia: Hb Plasencia [alpha125(H8)Leu-->Arg (alpha2). Hemoglobin · 2005
The sequence and analysis of duplication-rich human chromosome 16. Nature · 2004
Characterization of hemoglobin Bassett (alpha94Asp-->Ala), a variant with very low oxygen affinity. Am. J. Hematol. · 2004
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Screening for mutations in human alpha-globin genes by nonradioactive single-strand conformation polymorphism. Braz. J. Med. Biol. Res. · 2003
… and 104 more in the literature graph

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