Small ribosomal subunit protein uS13

Function

Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.

Classification

Family (Pfam)

PF00416 Ribosomal_S13

InterPro

Rbsml_uS13_C, Ribosomal_uS13, Ribosomal_uS13-like_H2TH, Ribosomal_uS13_bact, Ribosomal_uS13_CS

Functional cluster

Ribosomal S13 & Maturase Proteins

Gene Ontology · 6

• GO:0005829 cytosol
• GO:0015935 small ribosomal subunit
• GO:0019843 rRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0006412 translation

Drugs targeting this protein · 1

• RETAPAMULIN inhibitor

Related proteins · sequence + function similarity

• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00
• Small ribosomal subunit protein uS13 1.00

Literature · 2 cited papers

• Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events. J. Infect. Dis. · 2005
• Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc. Natl. Acad. Sci. U.S.A. · 2001