Large ribosomal subunit protein uL1

UniProt P66096 Organism Streptococcus pneumoniae (strain ATCC BAA-255 / R6) Gene rplA, spr0556

Also known as: rplA, spr0556

Function

Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.

Classification

Family (Pfam): PF00687 Ribosomal_L1
InterPro: Ribosom_uL1_bact, Ribosomal_uL1, Ribosomal_uL1-like, Ribosomal_uL1/biogenesis, Ribosomal_uL1_3-a/b-sand, Ribosomal_uL1_CS
Functional cluster: Glycolytic Enzymes & Elongation Factor Ts

Gene Ontology · 7

GO:0022625 cytosolic large ribosomal subunit
GO:0003729 mRNA binding
GO:0019843 rRNA binding
GO:0003735 structural constituent of ribosome
GO:0000049 tRNA binding
GO:0006417 regulation of translation
GO:0006412 translation

Drugs targeting this protein · 2

LINCOMYCIN HYDROCHLORIDE inhibitor
TROLEANDOMYCIN inhibitor

Related proteins · sequence + function similarity

Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 1.00
Large ribosomal subunit protein uL1 0.99
Large ribosomal subunit protein uL1 0.99

Literature · 1 cited papers

Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. · 2001

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