Platelet-activating factor acetylhydrolase IB subunit beta

UniProt P63005 Organism Mus musculus Gene Lis-1, Lis1, Pafah1b1, Pafaha

Also known as: Lis-1, Lis1, Pafah1b1, Pafaha

Function

Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in PAF inactivation. Regulates the PAF-AH (I) activity in a catalytic dimer composition-dependent manner (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (By similarity). May modulate the Reelin pathway through interaction of the PAF-AH (I) catalytic dimer with VLDLR.

Classification

Family (Pfam): PF24951 LisH_PAC1, PF00400 WD40
InterPro: Dynein_regulator_LIS1, LIS1_N, LisH, PAC1-like_LisH-like_dom, WD40/YVTN_repeat-like_dom_sf, WD40_PAC1, WD40_repeat_CS, WD40_repeat_dom_sf, WD40_rpt, WD_LIS1/nudF_dynein_reg
Functional cluster: Protein Serine/Threonine Kinases

Experimental structures · PDB · 2

1UUJ X-ray 1.75A
1VYH X-ray 3.40A

A predicted model is available from AlphaFold.

Gene Ontology · 84

Neighborhood · nearest proteins

Nearest neighbours of Platelet-activating factor acetylhydrolase IB subunit beta: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Nuclear distribution protein nudE-like 1 9 shared papers
Nuclear distribution protein nudE homolog 1 4 shared papers
Platelet-activating factor acetylhydrolase IB subunit alpha 4 shared papers
Platelet-activating factor acetylhydrolase IB subunit beta 5 shared papers
Platelet-activating factor acetylhydrolase IB subunit alpha2 1 shared papers
Nuclear distribution protein nudE-like 1 4 shared papers
Integrator complex subunit 13 1 shared papers
Nuclear distribution protein nudE homolog 1-A 1 shared papers
Platelet-activating factor acetylhydrolase IB subunit alpha2 1 shared papers
Platelet-activating factor acetylhydrolase IB subunit alpha1 1 shared papers
14-3-3 protein epsilon 1 shared papers
Nuclear distribution protein nudE-like 1 1 shared papers

Literature · 37 cited papers

Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. Mol. Biol. Cell · 2012
A tissue-specific atlas of mouse protein phosphorylation and expression. Cell · 2010
The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE · 2007
Regulation of cytoplasmic dynein ATPase by Lis1. J. Neurosci. · 2006
Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility. Nat. Neurosci. · 2006
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. Mol. Biol. Cell · 2006
Novel functional features of the Lis-H domain: role in protein dimerization, half-life and cellular localization. Cell Cycle · 2005
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration. Hum. Mol. Genet. · 2005
Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol. Cell. Biol. · 2005
Cytoplasmic LEK1 is a regulator of microtubule function through its interaction with the LIS1 pathway. Proc. Natl. Acad. Sci. U.S.A. · 2005
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. Neuron · 2004
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 25 more in the literature graph

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