Small ribosomal subunit protein eS32

Function

Component of the small ribosomal subunit (Probable) (Ref.8). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII.

Classification

Family (Pfam)

PF05162 Ribosomal_L41

InterPro

Ribosomal_eS32

Functional cluster

Bacterial Ribosomal Proteins

Experimental structures · PDB · 149

• 4UG0 EM
• 4V6X EM 5.00A
• 5A2Q EM 3.90A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5OA3 EM 4.30A
• 5VYC X-ray 6.00A
• 6G5H EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6OLE EM 3.10A
• … and 137 more

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0005783 endoplasmic reticulum
• GO:0003730 mRNA 3'-UTR binding
• GO:0048027 mRNA 5'-UTR binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 1.00
• Small ribosomal subunit protein eS32 0.99
• Small ribosomal subunit protein eS32 0.99
• Small ribosomal subunit protein eS32 eS32z/eS32y/eS32x/eS32w/eS32v 0.99
• Small ribosomal subunit protein eS32 0.99
• Small ribosomal subunit protein eS32 0.99

Literature · 6 cited papers

• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
• The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII. Biochem. Biophys. Res. Commun. · 1997
• Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41. Biochem. Biophys. Res. Commun. · 1992