Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

UniProt P62714 Organism Homo sapiens Gene PPP2CB EC 3.1.3.16

Also known as: PPP2CB

Function

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.

Classification

Family (Pfam): PF00149 Metallophos
InterPro: Calcineurin-like_PHP, Metallo-depent_PP-like, PPA2-like, Ser/Thr-sp_prot-phosphatase
Functional cluster: Serine/Threonine Protein Kinases

Gene Ontology · 19

Drugs targeting this protein · 1

LB-100 inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Middle T antigen 1 shared papers
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 5 shared papers
Protein phosphatase methylesterase 1 1 shared papers
Protein phosphatase methylesterase 1 1 shared papers
Serine/threonine-protein phosphatase 2A activator 1 shared papers
Serine/threonine-protein phosphatase 2A activator 2 1 shared papers
Large T antigen 1 shared papers
Serine/threonine-protein phosphatase 2A activator 1 1 shared papers
CTTNBP2 N-terminal-like protein 1 shared papers
Striatin-interacting protein 1 1 shared papers
Striatin-interacting proteins 2 1 shared papers
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform 1 shared papers

Literature · 12 cited papers

Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol. Cell. Proteomics · 2009
Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo. Genes Dev. · 2003
A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A. J. Biol. Chem. · 1999
The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. J. Biol. Chem. · 1994
The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit. Nucleic Acids Res. · 1988
Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes. Proc. Natl. Acad. Sci. U.S.A. · 1988
Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. EMBO J. · 1989
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell · 1990
Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. Biochemistry · 1991

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