Estrogen-related receptor gamma

Function

Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle.

Classification

Family (Pfam)

PF00104 Hormone_recep, PF00105 zf-C4

InterPro

Est_rcpt/est-rel_rcp, NHR-like_dom_sf, Nucl_hrmn_rcpt_lig-bd, Nuclear_hormone_rcpt_NR3, Nuclear_hrmn_rcpt, Oest-rel_rcp, Retinoic_acid_rcpt, Znf_hrmn_rcpt, Znf_NHR/GATA

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 43

• 1KV6 X-ray 2.70A
• 1TFC X-ray 2.40A
• 1VJB X-ray 3.20A
• 2E2R X-ray 1.60A
• 2EWP X-ray 2.30A
• 2GP7 X-ray 2.45A
• 2GPO X-ray 1.95A
• 2GPP X-ray 2.60A
• 2GPU X-ray 1.70A
• 2GPV X-ray 2.85A
• 2P7A X-ray 2.30A
• 2P7G X-ray 2.10A
• … and 31 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0000785 chromatin
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0050682 AF-2 domain binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0034056 estrogen response element binding
• GO:0042802 identical protein binding
• GO:0004879 nuclear receptor activity
• GO:0003707 nuclear steroid receptor activity
• GO:1990837 sequence-specific double-stranded DNA binding
• GO:0005496 steroid binding
• GO:0008270 zinc ion binding
• GO:0006351 DNA-templated transcription
• GO:0120162 positive regulation of cold-induced thermogenesis
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II
• GO:0048384 retinoic acid receptor signaling pathway

Drugs targeting this protein · 1

• AFIMOXIFENE antagonist

Related proteins · sequence + function similarity

• Estrogen-related receptor gamma 1.00
• Estrogen-related receptor gamma 0.99
• Steroid hormone receptor ERR2 0.95
• Steroid hormone receptor ERR2 0.94
• Steroid hormone receptor ERR2 0.94
• Retinoic acid receptor RXR-beta-B 0.88
• Retinoic acid receptor RXR-gamma-A 0.87
• Retinoic acid receptor RXR-alpha-A 0.87
• Hepatocyte nuclear factor 4-alpha 0.86
• Hepatocyte nuclear factor 4-alpha 0.86
• Hepatocyte nuclear factor 4-alpha 0.86
• Retinoic acid receptor RXR-gamma 0.86

Co-cited proteins · studied together in the literature

• Estrogen-related receptor gamma 1 shared papers
• Steroid hormone receptor ERR2 3 shared papers
• Steroid hormone receptor ERR1 3 shared papers
• Steroid hormone receptor ERR1 2 shared papers
• Steroid hormone receptor ERR2 1 shared papers
• Nuclear receptor-interacting protein 1 1 shared papers
• Proline-rich nuclear receptor coactivator 2 1 shared papers
• Nuclear receptor coactivator 1 1 shared papers
• PGC-1 and ERR-induced regulator in muscle protein 1 1 shared papers
• PGC-1 and ERR-induced regulator in muscle protein 1 1 shared papers
• Transducin-like enhancer protein 1 1 shared papers
• Peroxisome proliferator-activated receptor gamma coactivator 1-beta 1 shared papers

Literature · 18 cited papers

• Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J. Biol. Chem. · 2013
• An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha. Mol. Endocrinol. · 2010
• Transcriptional ERRgamma2-mediated activation is regulated by sentrin-specific proteases. Biochem. J. · 2009
• Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif. Mol. Endocrinol. · 2008
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. J. Biol. Chem. · 2006
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• PDSM, a motif for phosphorylation-dependent SUMO modification. Proc. Natl. Acad. Sci. U.S.A. · 2006
• Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg. Med. Chem. Lett. · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. Biochem. Biophys. Res. Commun. · 2003
• … and 6 more in the literature graph