Large ribosomal subunit protein eL8

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01248 Ribosomal_L7Ae

InterPro

eL8/uL1-like, Ribosomal_eL30-like_sf, Ribosomal_eL8-like_CS, Ribosomal_eL8/eL30/eS12/Gad45, Ribosomal_eL8/Nhp2, Ribosomal_eL8_euk

Functional cluster

Small-Subunit Ribosomal Proteins

Experimental structures · PDB · 161

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 149 more

A predicted model is available from AlphaFold.

Gene Ontology · 19

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0005730 nucleolus
• GO:0005634 nucleus
• GO:0005840 ribosome
• GO:0045202 synapse
• GO:0045296 cadherin binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0000470 maturation of LSU-rRNA
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL8 1.00
• Large ribosomal subunit protein eL8 1.00
• Large ribosomal subunit protein eL8 1.00
• Large ribosomal subunit protein eL8 1.00
• Large ribosomal subunit protein eL8 1.00
• Large ribosomal subunit protein eL8 0.99
• Large ribosomal subunit protein eL8 0.98
• Large ribosomal subunit protein eL8 0.96
• Large ribosomal subunit protein eL8 0.95
• Large ribosomal subunit protein eL8z 0.94
• Large ribosomal subunit protein eL8y 0.94
• Large ribosomal subunit protein eL8 0.94

Co-cited proteins · studied together in the literature

• High affinity nerve growth factor receptor 1 shared papers
• Eukaryotic translation initiation factor 6 1 shared papers
• Eukaryotic translation initiation factor 6 1 shared papers
• RNA helicase MOV-10 1 shared papers
• RISC-loading complex subunit TARBP2 1 shared papers
• Endoribonuclease Dicer 1 shared papers
• Protein argonaute-2 1 shared papers

Literature · 17 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• MicroRNA silencing through RISC recruitment of eIF6. Nature · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• DNA sequence and analysis of human chromosome 9. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 5 more in the literature graph