Large ribosomal subunit protein eL15

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF00827 Ribosomal_L15e

InterPro

Rbsml_eL15_core_dom_sf, Ribosomal_eL15, Ribosomal_eL15_CS, Ribosomal_uL23/eL15/eS24_sf

Functional cluster

Core Ribosomal Proteins (L2/L14/L16)

Experimental structures · PDB · 153

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 141 more

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0005634 nucleus
• GO:0005840 ribosome
• GO:0045202 synapse
• GO:0045296 cadherin binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 12 MONDO:0014245

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL15 1.00
• Large ribosomal subunit protein eL15 1.00
• Large ribosomal subunit protein eL15 1.00
• Large ribosomal subunit protein eL15 1.00
• Large ribosomal subunit protein eL15 1.00
• Large ribosomal subunit protein eL15 1.00
• Large ribosomal subunit protein eL15 0.99
• Large ribosomal subunit protein eL15 0.98
• Large ribosomal subunit protein eL15 0.98
• Large ribosomal subunit protein eL15 0.98
• Large ribosomal subunit protein eL15 0.98
• Large ribosomal subunit protein eL15 0.98

Co-cited proteins · studied together in the literature

• Antiviral innate immune response effector IFIT1 1 shared papers

Literature · 17 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nat. Commun. · 2014
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Novel deletion of RPL15 identified by array-comparative genomic hybridization in Diamond-Blackfan anemia. Hum. Genet. · 2013
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells. DNA Cell Biol. · 2011
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• … and 5 more in the literature graph