Potassium channel subfamily K member 10
Also known as: KCNK10, TREK2
Function
K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). Permeable to other monovalent ions such as Rb(+) and Cs(+).
Classification
- Family (Pfam)
- PF07885 Ion_trans_2
- InterPro
- 2pore_dom_K_chnl, 2pore_dom_K_chnl_TREK, K_chnl_dom
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 8
- 4BW5 X-ray 3.20A
- 4XDJ X-ray 3.80A
- 4XDK X-ray 3.60A
- 4XDL X-ray 3.50A
- 8QZ1 X-ray 3.59A
- 8QZ2 X-ray 3.50A
- 8QZ3 X-ray 2.40A
- 8QZ4 X-ray 3.20A
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0034702 monoatomic ion channel complex
- GO:0005886 plasma membrane
- GO:0098782 mechanosensitive potassium channel activity
- GO:0015271 outward rectifier potassium channel activity
- GO:0005267 potassium channel activity
- GO:0022841 potassium ion leak channel activity
- GO:1904551 cellular response to arachidonate
- GO:0071805 potassium ion transmembrane transport
- GO:0007165 signal transduction
Drugs targeting this protein · 5
- SEVOFLURANE opener
- DESFLURANE opener
- ISOFLURANE opener
- ENFLURANE opener
- HALOTHANE opener
Related proteins · sequence + function similarity
- Potassium channel subfamily K member 10 0.99
- Potassium channel subfamily K member 10 0.98
- Potassium channel subfamily K member 2 0.91
- Potassium channel subfamily K member 2 0.91
- Potassium channel subfamily K member 2 0.90
- Two pore potassium channel protein sup-9 0.78
- TWiK family of potassium channels protein 18 0.78
- Potassium channel subfamily K member 9 0.78
- TWiK family of potassium channels protein 9 0.77
- Potassium channel subfamily K member 9 0.76
- Potassium channel subfamily K member 9 0.76
- Uncoordinated protein 58 0.75
Co-cited proteins · studied together in the literature
- Potassium channel subfamily K member 10 1 shared papers
- Potassium channel subfamily K member 4 2 shared papers
- Potassium channel subfamily K member 5 2 shared papers
- Potassium channel subfamily K member 2 2 shared papers
- Potassium channel subfamily K member 2 2 shared papers
- Potassium channel subfamily K member 16 2 shared papers
- Potassium channel subfamily K member 13 1 shared papers
- Potassium channel subfamily K member 18 2 shared papers
- Potassium channel subfamily K member 10 1 shared papers
- Potassium channel subfamily K member 17 1 shared papers
- Potassium channel subfamily K member 18 1 shared papers
- Potassium channel subfamily K member 2 1 shared papers
Literature · 10 cited papers
- Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2. Nat. Commun. · 2024
- Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron · 2019
- A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels. Cell · 2016
- K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science · 2015
- Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. Br. J. Pharmacol. · 2008
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The DNA sequence and analysis of human chromosome 14. Nature · 2003
- Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J. Physiol. (Lond.) · 2002
- Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids and Gs, Gi, and Gq protein-coupled receptors. J. Biol. Chem. · 2000