P2X purinoceptor 3
Also known as: P2RX3
Function
Extracellular ATP-activated non-selective cation channel. Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity).
Classification
- Family (Pfam)
- PF00864 P2X_receptor
- InterPro
- P2X3_purnocptor, P2X_extracellular_dom_sf, P2X_purnocptor, P2X_receptor, P2X_RECEPTOR_CS
- Functional cluster
- Venom Serine Proteases & Phospholipase A2
Experimental structures · PDB · 13
- 5SVJ X-ray 2.98A
- 5SVK X-ray 2.77A
- 5SVL X-ray 2.90A
- 5SVM X-ray 3.09A
- 5SVP X-ray 3.30A
- 5SVQ X-ray 3.25A
- 5SVR X-ray 3.13A
- 5SVS X-ray 4.03A
- 5SVT X-ray 3.79A
- 5YVE X-ray 3.40A
- 6AH4 X-ray 3.30A
- 6AH5 X-ray 3.82A
- … and 1 more
A predicted model is available from AlphaFold.
Gene Ontology · 18
- GO:0030424 axon
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0005886 plasma membrane
- GO:0098794 postsynapse
- GO:0043235 receptor complex
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0005524 ATP binding
- GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
- GO:0046872 metal ion binding
- GO:0001614 purinergic nucleotide receptor activity
- GO:0070588 calcium ion transmembrane transport
- GO:0071318 cellular response to ATP
- GO:0050804 modulation of chemical synaptic transmission
- GO:0010524 positive regulation of calcium ion transport into cytosol
- GO:0050850 positive regulation of calcium-mediated signaling
- GO:0070207 protein homotrimerization
- GO:0007165 signal transduction
- GO:0055085 transmembrane transport
Drugs targeting this protein · 3
- GEFAPIXANT antagonist
- GEFAPIXANT CITRATE antagonist
- CAMLIPIXANT antagonist
Related proteins · sequence + function similarity
- P2X purinoceptor 3 0.99
- P2X purinoceptor 3 0.99
- P2X purinoceptor 5 0.94
- P2X purinoceptor 4a 0.93
- P2X purinoceptor 5 0.93
- P2X purinoceptor 4 0.90
- P2X purinoceptor 4 0.90
- P2X purinoceptor 4 0.90
- P2X purinoceptor 4 0.89
- P2X purinoceptor 5 0.85
- P2X purinoceptor 6 0.83
- P2X purinoceptor 1 0.82
Co-cited proteins · studied together in the literature
- P2X purinoceptor 4 1 shared papers
- P2X purinoceptor 3 1 shared papers
- P2X purinoceptor 1 1 shared papers
- P2X purinoceptor 2 1 shared papers
Literature · 7 cited papers
- Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. Elife · 2019
- Druggable negative allosteric site of P2X3 receptors. Proc. Natl. Acad. Sci. U.S.A. · 2018
- X-ray structures define human P2X(3) receptor gating cycle and antagonist action. Nature · 2016
- Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur. J. Pharmacol. · 1999
- Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. Mol. Pharmacol. · 1997
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