Sodium/potassium-transporting ATPase subunit gamma

Function

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

Classification

Family (Pfam)

PF02038 ATP1G1_PLM_MAT8

InterPro

ATNG, FXYD_motif, Ion-transport_regulator_FXYD

Functional cluster

Photosystem II Reaction-Center & Antimicrobial Peptides

Experimental structures · PDB · 4

• 2MKV NMR
• 7E1Z EM 3.20A
• 7E20 EM 2.70A
• 7E21 EM 2.90A

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0016323 basolateral plasma membrane
• GO:0070062 extracellular exosome
• GO:0005886 plasma membrane
• GO:0005890 sodium:potassium-exchanging ATPase complex
• GO:0001671 ATPase activator activity
• GO:0030674 protein-macromolecule adaptor activity
• GO:0017080 sodium channel regulator activity
• GO:0071475 cellular hyperosmotic salinity response
• GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
• GO:0008285 negative regulation of cell population proliferation
• GO:1903278 positive regulation of sodium ion export across plasma membrane
• GO:1990573 potassium ion import across plasma membrane
• GO:1902600 proton transmembrane transport
• GO:0036376 sodium ion export across plasma membrane
• GO:0055085 transmembrane transport

Disease associations

• renal hypomagnesemia 2 MONDO:0007937

Drugs targeting this protein · 6

• DESLANOSIDE inhibitor
• DIGOXIN inhibitor
• ISTAROXIME inhibitor
• DIGITOXIN inhibitor
• ACETYLDIGITOXIN inhibitor
• LANATOSIDE C inhibitor

Related proteins · sequence + function similarity

• Sodium/potassium-transporting ATPase subunit gamma 0.94
• Sodium/potassium-transporting ATPase subunit gamma 0.93
• Sodium/potassium-transporting ATPase subunit gamma 0.91
• Sodium/potassium-transporting ATPase subunit gamma 0.91
• Sodium/potassium-transporting ATPase subunit gamma 0.79
• Phospholemman 0.75
• Phospholemman 0.75
• Phospholemman 0.74
• Phospholemman 0.74
• Phospholemman 0.72
• Phospholemman 0.71
• FXYD domain-containing ion transport regulator 3 0.71

Literature · 4 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. Biochem. Biophys. Res. Commun. · 2000
• Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase gamma-subunit. Nat. Genet. · 2000
• Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma-subunit. Biochim. Biophys. Acta · 1997