Kinesin-like protein KIF11

UniProt P52732 Organism Homo sapiens Gene EG5, KIF11, KNSL1, TRIP5

Also known as: EG5, KIF11, KNSL1, TRIP5

Function

Motor protein required for establishing a bipolar spindle and thus contributing to chromosome congression during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface.

Classification

Family (Pfam): PF00225 Kinesin, PF13931 Microtub_bind
InterPro: KIF11-like, KIF11-like_kin_motor_dom, Kinesin-assoc_MT-bd_dom, Kinesin_motor_CS, Kinesin_motor_dom, Kinesin_motor_dom_sf, P-loop_NTPase
Functional cluster: Zinc-Finger & Chromatin Regulatory Proteins

Experimental structures · PDB · 62

1II6 X-ray 2.10A
1Q0B X-ray 1.90A
1X88 X-ray 1.80A
1YRS X-ray 2.50A
2FKY X-ray 2.30A
2FL2 X-ray 2.50A
2FL6 X-ray 2.50A
2FME X-ray 2.10A
2G1Q X-ray 2.51A
2GM1 X-ray 2.30A
2IEH X-ray 2.70A
2PG2 X-ray 1.85A
… and 50 more

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability MONDO:0007918

Drugs targeting this protein · 4

AZD-4877 inhibitor
LITRONESIB inhibitor
ISPINESIB inhibitor
FILANESIB inhibitor

Related proteins · sequence + function similarity

Kinesin-like protein KIF11 0.98
Kinesin-like protein KIF11-A 0.94
Kinesin-like protein KIF11-B 0.93
Kinesin-like protein KIF11 0.92
Kinesin-like protein Klp61F 0.87
Kinesin-like protein KIN-5C 0.86
Chromosome-associated kinesin KIF4B 0.86
Kinesin-like protein KIN-5A 0.86
Kinesin-like protein KIN-5C 0.86
Kinesin-like protein KIN-5D 0.84
Kinesin-like protein KIF27 0.84
Kinesin-like protein KIF15 0.83

Co-cited proteins · studied together in the literature

Kinesin-like protein Klp61F 1 shared papers
Cytosolic carboxypeptidase 2 1 shared papers
Targeting protein for Xklp2 1 shared papers
Retinoic acid receptor responder protein 1 1 shared papers
RNA-binding protein 10 1 shared papers
Deubiquitinase MYSM1 1 shared papers
Kinesin-like protein KIF11-A 1 shared papers
E3 ubiquitin-protein ligase UHRF1 1 shared papers
Kinesin-like protein KIF11-B 1 shared papers
Serine/threonine-protein kinase Nek9 1 shared papers
Serine/threonine-protein kinase Nek6 1 shared papers
Pachytene checkpoint protein 2 homolog 1 shared papers

Literature · 21 cited papers

UHRF1 promotes spindle assembly and chromosome congression by catalyzing EG5 polyubiquitination. J. Cell Biol. · 2023
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface. J. Cell Biol. · 2013
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. Am. J. Hum. Genet. · 2012
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the alpha-tubulin tyrosination cycle. Cancer Res. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. J. Cell Sci. · 2008
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
… and 9 more in the literature graph

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