C-C chemokine receptor type 9
Also known as: CCR9, GPR28
Function
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- CCR1-9-like, Chemokine_CCR9, Chemokine_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 1
- 5LWE X-ray 2.80A
A predicted model is available from AlphaFold.
Gene Ontology · 13
- GO:0009986 cell surface
- GO:0009897 external side of plasma membrane
- GO:0005886 plasma membrane
- GO:0019957 C-C chemokine binding
- GO:0016493 C-C chemokine receptor activity
- GO:0004950 chemokine receptor activity
- GO:0019722 calcium-mediated signaling
- GO:0060326 cell chemotaxis
- GO:0006968 cellular defense response
- GO:0006935 chemotaxis
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006955 immune response
- GO:0007204 positive regulation of cytosolic calcium ion concentration
Drugs targeting this protein · 1
- VERCIRNON antagonist
Related proteins · sequence + function similarity
- C-C chemokine receptor type 9 0.99
- C-C chemokine receptor type 9 0.99
- C-C chemokine receptor type 7 0.96
- C-C chemokine receptor type 7 0.96
- C-C chemokine receptor type 7 0.96
- C-C chemokine receptor type 2 0.95
- C-C chemokine receptor type 2 0.95
- C-X-C chemokine receptor type 6 0.95
- C-C chemokine receptor type 5 0.94
- C-C chemokine receptor type 5 0.94
- C-C chemokine receptor type 5 0.94
- C-C chemokine receptor type 5 0.94
Co-cited proteins · studied together in the literature
- C-C chemokine receptor type 9 1 shared papers
- C-C motif chemokine 25 1 shared papers
Literature · 4 cited papers
- Intracellular allosteric antagonism of the CCR9 receptor. Nature · 2016
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- CCR9A and CCR9B: two receptors for the chemokine CCL25/TECK/Ck beta-15 that differ in their sensitivities to ligand. J. Immunol. · 2000
- Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol. · 1999
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