lmmol · Proteins

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

UniProt P51532 Organism Homo sapiens Gene BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4 EC 3.6.4.-

Also known as: BAF190A, BRG1, SMARCA4, SNF2B, SNF2L4

Function

ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity).

Classification

Family (Pfam)
PF07533 BRK, PF00439 Bromodomain, PF00271 Helicase_C, PF07529 HSA, PF08880 QLQ, PF14619 SnAC, PF00176 SNF2-rel_dom
InterPro
BRG1_ATP-bd, BRK_domain, BRK_sf, Bromodomain, Bromodomain-like_sf, Bromodomain_CS, Gln-Leu-Gln_QLQ, Helicase_ATP-bd, Helicase_C-like, HSA_dom, P-loop_NTPase, SnAC, SNF2-like_sf, SNF2/RAD54-like_C, SNF2_N
Functional cluster
RNA-Polymerase II Transcription Factors

Experimental structures · PDB · 21

A predicted model is available from AlphaFold.

Gene Ontology · 63

Disease associations

Neighborhood · nearest proteins

BAF190ABaf190aBaf190aBAF190ABAF190BAREB6ACTL6A
Nearest neighbours of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 42 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.