Methionine aminopeptidase 2

UniProt P50579 Organism Homo sapiens Gene METAP2, MNPEP, P67EIF2 EC 3.4.11.18

Also known as: METAP2, MNPEP, P67EIF2

Function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.

Classification

Family (Pfam): PF00557 Peptidase_M24
InterPro: Creatinase/aminopeptidase-like, Met_Aminopeptidase_Type2, Pept_M24, Pept_M24_MAP, Pept_M24A_MAP2, Pept_M24A_MAP2_BS, WH-like_DNA-bd_sf, WH_DNA-bd_sf
Functional cluster: Oxidoreductases, Catalases & Peroxidases

Experimental structures · PDB · 40

1B59 X-ray 1.80A
1B6A X-ray 1.60A
1BN5 X-ray 1.80A
1BOA X-ray 1.80A
1KQ0 X-ray 2.00A
1KQ9 X-ray 1.90A
1QZY X-ray 1.60A
1R58 X-ray 1.90A
1R5G X-ray 2.00A
1R5H X-ray 2.40A
1YW7 X-ray 1.85A
1YW8 X-ray 2.65A
… and 28 more

A predicted model is available from AlphaFold.

Gene Ontology · 10

Drugs targeting this protein · 3

TOSEDOSTAT inhibitor
BELORANIB inhibitor
ACLIMOSTAT inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Methionine aminopeptidase 1 shared papers
Methionine aminopeptidase 2 1 shared papers
Methionine aminopeptidase 2 1 shared papers
14-3-3 protein gamma 1 shared papers

Literature · 22 cited papers

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein. World J. Biol. Chem. · 2010
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Biochemistry · 2010
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J. Med. Chem. · 2007
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids. Bioorg. Med. Chem. Lett. · 2007
The finished DNA sequence of human chromosome 12. Nature · 2006
Human methionine aminopeptidase type 2 in complex with L- and D-methionine. Bioorg. Med. Chem. Lett. · 2006
… and 10 more in the literature graph

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