GMP synthase [glutamine-hydrolyzing]

Function

Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.

Classification

Family (Pfam)

PF00117 GATase, PF00958 GMP_synt_C, PF02540 NAD_synthase

InterPro

Class_I_gatase-like, GATASE, GMP_synth_C, GMP_synth_GATase, GMPS_ATP_PPase_dom, NAD/GMP_synthase, Rossmann-like_a/b/a_fold

Functional cluster

Argininosuccinate Synthase & tRNA Ligases

Experimental structures · PDB · 2

• 2VPI X-ray 2.40A
• 2VXO X-ray 2.50A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005829 cytosol
• GO:0005524 ATP binding
• GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
• GO:0003921 GMP synthase activity
• GO:0006177 GMP biosynthetic process
• GO:0009113 purine nucleobase biosynthetic process
• GO:0009168 purine ribonucleoside monophosphate biosynthetic process

Drugs targeting this protein · 1

• MIZORIBINE inhibitor

Related proteins · sequence + function similarity

• GMP synthase [glutamine-hydrolyzing] 1.00
• GMP synthase [glutamine-hydrolyzing] 1.00
• GMP synthase [glutamine-hydrolyzing] 1.00
• Probable GMP synthase [glutamine-hydrolyzing] 0.84
• GMP synthase [glutamine-hydrolyzing] 0.79
• GMP synthase [glutamine-hydrolyzing] 0.78
• GMP synthase [glutamine-hydrolyzing] 0.78
• GMP synthase [glutamine-hydrolyzing] 0.78
• GMP synthase [glutamine-hydrolyzing] 0.77
• GMP synthase [glutamine-hydrolyzing] 0.77
• GMP synthase [glutamine-hydrolyzing] 0.77
• GMP synthase [glutamine-hydrolyzing] 0.77

Co-cited proteins · studied together in the literature

• Histone-lysine N-methyltransferase 2A 1 shared papers

Literature · 14 cited papers

• Substrate specificity and oligomerization of human GMP synthetase. J. Mol. Biol. · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 2 more in the literature graph