Casein kinase I isoform epsilon

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation.

Classification

Family (Pfam)

PF00069 Pkinase

InterPro

CK1_Ser-Thr_kinase, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser/Thr_kinase_AS

Functional cluster

Protein Serine/Threonine Kinases

Experimental structures · PDB · 2

• 4HNI X-ray 2.74A
• 4HOK X-ray 2.77A

A predicted model is available from AlphaFold.

Gene Ontology · 28

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0030426 growth cone
• GO:0043025 neuronal cell body
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:1990904 ribonucleoprotein complex
• GO:0005524 ATP binding
• GO:0004672 protein kinase activity
• GO:0106310 protein serine kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0003723 RNA binding
• GO:0060070 canonical Wnt signaling pathway
• GO:1990090 cellular response to nerve growth factor stimulus
• GO:0048512 circadian behavior
• GO:0032922 circadian regulation of gene expression
• GO:0006281 DNA repair
• GO:0006897 endocytosis
• GO:0051058 negative regulation of small GTPase mediated signal transduction
• GO:0035567 non-canonical Wnt signaling pathway
• GO:1902004 positive regulation of amyloid-beta formation
• GO:0090263 positive regulation of canonical Wnt signaling pathway
• GO:2000052 positive regulation of non-canonical Wnt signaling pathway
• GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• GO:0006468 protein phosphorylation
• GO:0042752 regulation of circadian rhythm
• GO:0032880 regulation of protein localization
• GO:0007165 signal transduction

Drugs targeting this protein · 1

• UMBRALISIB TOSYLATE inhibitor

Related proteins · sequence + function similarity

• Casein kinase I isoform epsilon 0.99
• Casein kinase I isoform epsilon 0.99
• Casein kinase I isoform delta 0.97
• Casein kinase I isoform delta 0.97
• Casein kinase I isoform delta 0.97
• Casein kinase I isoform delta 0.97
• Casein kinase I isoform delta 0.97
• Casein kinase I isoform delta 0.97
• Casein kinase I isoform delta-B 0.97
• Casein kinase I isoform delta-A 0.96
• Casein kinase I isoform delta 0.96
• Casein kinase 1-like protein 1 0.92

Co-cited proteins · studied together in the literature

• Proto-oncogene FRAT1 1 shared papers
• Casein kinase I isoform delta 5 shared papers
• Putative ATP-dependent RNA helicase an3 1 shared papers
• Dysbindin domain-containing protein 2 1 shared papers
• Casein kinase I isoform alpha 2 shared papers
• Period circadian protein homolog 1 2 shared papers
• Zinc finger protein SNAI1 1 shared papers
• Suppressor of cytokine signaling 3 1 shared papers
• ATP-dependent RNA helicase DDX3X 2 shared papers
• Low-density lipoprotein receptor-related protein 5 1 shared papers
• Low-density lipoprotein receptor-related protein 6 1 shared papers
• Cryptochrome-2 1 shared papers

Literature · 27 cited papers

• The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms. Sci. Signal. · 2018
• A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1epsilon. J. Cell Sci. · 2018
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-beta-catenin signaling. Science · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J. Med. Chem. · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
• Large-scale proteomics analysis of the human kinome. Mol. Cell. Proteomics · 2009
• … and 15 more in the literature graph