Troponin I, fast skeletal muscle

Function

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Classification

Family (Pfam)

PF00992 Troponin

InterPro

Troponin, Troponin_I, Troponin_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 2

• 2MKP NMR
• 7KAA NMR

A predicted model is available from AlphaFold.

Gene Ontology · 8

• GO:0005829 cytosol
• GO:0005634 nucleus
• GO:0005861 troponin complex
• GO:0003779 actin binding
• GO:0031014 troponin T binding
• GO:0060048 cardiac muscle contraction
• GO:0045893 positive regulation of DNA-templated transcription
• GO:0003009 skeletal muscle contraction

Disease associations

• distal arthrogryposis type 2B1 MONDO:0020820

Drugs targeting this protein · 2

• TIRASEMTIV activator
• RELDESEMTIV activator

Related proteins · sequence + function similarity

• Troponin I, fast skeletal muscle 1.00
• Troponin I, fast skeletal muscle 0.99
• Troponin I, fast skeletal muscle 0.99
• Troponin I, slow skeletal muscle 0.93
• Troponin I, slow skeletal muscle 0.93
• Troponin I, slow skeletal muscle 0.92
• Troponin I, fast skeletal muscle 0.91
• Troponin I, fast skeletal muscle 0.91
• Troponin I, slow skeletal muscle 0.90
• Troponin I, cardiac muscle 0.84
• Troponin I, cardiac muscle 0.84
• Troponin I, cardiac muscle 0.83

Co-cited proteins · studied together in the literature

• Tropomyosin beta chain 1 shared papers

Literature · 5 cited papers

• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes. Am. J. Hum. Genet. · 2003
• Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2). Gene · 2000
• Sequencing of a cDNA encoding the human fast-twitch skeletal muscle isoform of troponin I. Biochim. Biophys. Acta · 1994