Sodium- and chloride-dependent glycine transporter 1
Also known as: SLC6A9
Function
Sodium- and chloride-dependent glycine transporter. Essential for regulating glycine concentrations at inhibitory glycinergic synapses.
Classification
- Family (Pfam)
- PF00209 SNF
- InterPro
- Na/ntran_symport, Na/ntran_symport_glycine_GLY1, SNS_sf
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 9
- 6ZBV X-ray 3.40A
- 6ZPL X-ray 3.94A
- 8WFI EM 2.58A
- 8WFJ EM 3.35A
- 8WFK EM 3.22A
- 8WFL EM 3.03A
- 9J8B EM 3.90A
- 9J8C EM 2.90A
- 9J8D EM 3.00A
A predicted model is available from AlphaFold.
Gene Ontology · 26
- GO:0016324 apical plasma membrane
- GO:0009925 basal plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0031045 dense core granule
- GO:0005768 endosome
- GO:0098686 hippocampal mossy fiber to CA3 synapse
- GO:0016328 lateral plasma membrane
- GO:0016020 membrane
- GO:0098688 parallel fiber to Purkinje cell synapse
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0045211 postsynaptic membrane
- GO:0042734 presynaptic membrane
- GO:0030672 synaptic vesicle membrane
- GO:0005283 amino acid:sodium symporter activity
- GO:0015187 glycine transmembrane transporter activity
- GO:0015375 glycine:sodium symporter activity
- GO:1903804 glycine import across plasma membrane
- GO:0015816 glycine transport
- GO:0006836 neurotransmitter transport
- GO:0001504 neurotransmitter uptake
- GO:0070455 positive regulation of heme biosynthetic process
- GO:0046985 positive regulation of hemoglobin biosynthetic process
- GO:0060092 regulation of synaptic transmission, glycinergic
- GO:0035725 sodium ion transmembrane transport
- GO:0150104 transport across blood-brain barrier
Disease associations
- atypical glycine encephalopathy MONDO:0015010
- scoliosis, isolated, susceptibility to, 6 MONDO:0980986
Drugs targeting this protein · 3
- BITOPERTIN inhibitor
- ORG-25935 inhibitor
- PF-03463275 inhibitor
Related proteins · sequence + function similarity
- Sodium- and chloride-dependent glycine transporter 1 0.99
- Sodium- and chloride-dependent glycine transporter 1 0.97
- Sodium- and chloride-dependent glycine transporter 1 0.97
- Sodium- and chloride-dependent GABA transporter 2 0.95
- Sodium-dependent proline transporter 0.94
- Sodium- and chloride-dependent GABA transporter 2 0.94
- Creatine transporter 0.94
- Sodium- and chloride-dependent GABA transporter 2 0.94
- Sodium- and chloride-dependent glycine transporter 1 0.94
- Sodium- and chloride-dependent creatine transporter 1 0.94
- Sodium- and chloride-dependent GABA transporter 2 0.93
- Sodium-dependent proline transporter 0.93
Co-cited proteins · studied together in the literature
- Sodium- and chloride-dependent glycine transporter 1 1 shared papers
Literature · 6 cited papers
- Impaired glycine neurotransmission causes adolescent idiopathic scoliosis. J. Clin. Invest. · 2024
- Loss of Glycine Transporter 1 Causes a Subtype of Glycine Encephalopathy with Arthrogryposis and Mildly Elevated Cerebrospinal Fluid Glycine. Am. J. Hum. Genet. · 2016
- Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans. Hum. Genet. · 2016
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. Mol. Pharmacol. · 1994
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