P2Y purinoceptor 1
Also known as: P2RY1
Function
Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, P2Y1_rcpt
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 5
A predicted model is available from AlphaFold.
Gene Ontology · 48
- GO:0016324 apical plasma membrane
- GO:0016323 basolateral plasma membrane
- GO:0044297 cell body
- GO:0009986 cell surface
- GO:0005929 cilium
- GO:0030425 dendrite
- GO:0098978 glutamatergic synapse
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0045211 postsynaptic membrane
- GO:0048787 presynaptic active zone membrane
- GO:0031686 A1 adenosine receptor binding
- GO:0043531 ADP binding
- GO:0005524 ATP binding
- GO:0001621 G protein-coupled ADP receptor activity
- GO:0045031 G protein-coupled ATP receptor activity
- GO:0045028 G protein-coupled purinergic nucleotide receptor activity
- GO:0046982 protein heterodimerization activity
- GO:0097110 scaffold protein binding
- GO:0038023 signaling receptor activity
- GO:0030545 signaling receptor regulator activity
- GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
- GO:0097746 blood vessel diameter maintenance
- GO:0007166 cell surface receptor signaling pathway
- GO:0071318 cellular response to ATP
- GO:0071415 cellular response to purine-containing compound
- GO:0042755 eating behavior
- GO:0001973 G protein-coupled adenosine receptor signaling pathway
- GO:0035589 G protein-coupled purinergic nucleotide receptor signaling pathway
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0008347 glial cell migration
- GO:0010700 negative regulation of norepinephrine secretion
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0030168 platelet activation
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0070374 positive regulation of ERK1 and ERK2 cascade
- GO:0046887 positive regulation of hormone secretion
- GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
- GO:0060406 positive regulation of penile erection
- GO:0045944 positive regulation of transcription by RNA polymerase II
- GO:0072659 protein localization to plasma membrane
- GO:0008360 regulation of cell shape
- GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
- GO:2000300 regulation of synaptic vesicle exocytosis
- GO:0090075 relaxation of muscle
- GO:0070848 response to growth factor
- GO:0009612 response to mechanical stimulus
- GO:0023019 signal transduction involved in regulation of gene expression
Drugs targeting this protein · 1
- DIQUAFOSOL TETRASODIUM agonist
Related proteins · sequence + function similarity
- P2Y purinoceptor 1 1.00
- P2Y purinoceptor 1 1.00
- P2Y purinoceptor 1 1.00
- P2Y purinoceptor 1 1.00
- P2Y purinoceptor 1 0.99
- P2Y purinoceptor 1 0.99
- 2-oxoglutarate receptor 1 0.95
- 2-oxoglutarate receptor 1 0.95
- 2-oxoglutarate receptor 1 0.95
- Succinate receptor 1 0.93
- Succinate receptor 1 0.93
- Cysteinyl leukotriene receptor 2 0.93
Literature · 8 cited papers
- Two disparate ligand-binding sites in the human P2Y1 receptor. Nature · 2015
- Phosphoproteome of resting human platelets. J. Proteome Res. · 2008
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. J. Biol. Chem. · 1998
- The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. · 1997
- Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. Gene · 1996
- Cloning and tissue distribution of the human P2Y1 receptor. Biochem. Biophys. Res. Commun. · 1996
- Cloning and chromosomal localization of the human P2Y1 purinoceptor. Biochem. Biophys. Res. Commun. · 1996
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