Utrophin

Function

May play a role in anchoring the cytoskeleton to the plasma membrane.

Classification

Family (Pfam)

PF00307 CH, PF09068 EF-hand_2, PF09069 EF-hand_3, PF00435 Spectrin, PF00569 ZZ

InterPro

Actinin_actin-bd_CS, CH_dom, CH_dom_sf, Dystrophin/utrophin, EF-hand-dom_pair, EF-hand_dom_typ1, EF-hand_dom_typ2, KCMF1/Dystrophin, Spectrin/alpha-actinin, Spectrin_repeat, WW_dom, WW_dom_sf, Znf_ZZ, Znf_ZZ_sf

Functional cluster

ATP Synthase Gamma Subunit & related

Experimental structures · PDB · 3

• 1BHD X-ray 2.00A
• 1QAG X-ray 3.00A
• 6M5G EM 3.60A

A predicted model is available from AlphaFold.

Gene Ontology · 23

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005829 cytosol
• GO:0016010 dystrophin-associated glycoprotein complex
• GO:0070062 extracellular exosome
• GO:0030175 filopodium
• GO:0031527 filopodium membrane
• GO:0016020 membrane
• GO:0031594 neuromuscular junction
• GO:0005886 plasma membrane
• GO:0045211 postsynaptic membrane
• GO:0032991 protein-containing complex
• GO:0042383 sarcolemma
• GO:0003779 actin binding
• GO:0005178 integrin binding
• GO:0019901 protein kinase binding
• GO:0017166 vinculin binding
• GO:0008270 zinc ion binding
• GO:0006936 muscle contraction
• GO:0007517 muscle organ development
• GO:0001954 positive regulation of cell-matrix adhesion
• GO:1902305 regulation of sodium ion transmembrane transport
• GO:0099536 synaptic signaling

Drugs targeting this protein · 1

• EZUTROMID modulator

Related proteins · sequence + function similarity

• Utrophin 0.98
• Dystrophin 0.95
• Dystrophin 0.95
• Dystrophin 0.95
• Dystrophin 0.95
• Dystrophin 0.94
• Dystrophin 0.93
• Nesprin-1 0.90
• Nesprin-1 0.90
• Nesprin-2 0.83
• Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 0.83
• Periplakin 0.83

Co-cited proteins · studied together in the literature

• Dystroglycan 1 2 shared papers
• Synemin 1 shared papers
• Beta-1-syntrophin 1 shared papers
• Dystrobrevin alpha 2 shared papers
• Dystrophin 2 shared papers
• Dystrophin 1 shared papers
• Alpha-1-syntrophin 1 shared papers
• Beta-2-syntrophin 1 shared papers

Literature · 21 cited papers

• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• The actin binding affinity of the utrophin tandem calponin-homology domain is primarily determined by its N-terminal domain. Biochemistry · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
• Interactions of intermediate filament protein synemin with dystrophin and utrophin. Biochem. Biophys. Res. Commun. · 2006
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin. J. Cell Sci. · 2000
• … and 9 more in the literature graph