B1 bradykinin receptor
Also known as: BDKRB1, BRADYB1
Function
This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Brdyknn_1_rcpt, Brdyknn_rcpt, CCR1-9-like, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 1
- 7EIB EM 3.00A
A predicted model is available from AlphaFold.
Gene Ontology · 14
- GO:0005783 endoplasmic reticulum
- GO:0005886 plasma membrane
- GO:0004947 bradykinin receptor activity
- GO:0042277 peptide binding
- GO:0016477 cell migration
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0045776 negative regulation of blood pressure
- GO:0030308 negative regulation of cell growth
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0002687 positive regulation of leukocyte migration
- GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
- GO:0032496 response to lipopolysaccharide
- GO:0009612 response to mechanical stimulus
Drugs targeting this protein · 2
- SAFOTIBANT antagonist
- MK0686 antagonist
Related proteins · sequence + function similarity
- B1 bradykinin receptor 1.00
- B1 bradykinin receptor 1.00
- B1 bradykinin receptor 1.00
- B1 bradykinin receptor 1.00
- B1 bradykinin receptor 0.98
- B1 bradykinin receptor 0.97
- B1 bradykinin receptor 0.97
- B1 bradykinin receptor 0.96
- B1 bradykinin receptor 0.96
- B1 bradykinin receptor 0.95
- B2 bradykinin receptor 0.92
- B2 bradykinin receptor 0.91
Co-cited proteins · studied together in the literature
- B1 bradykinin receptor 1 shared papers
Literature · 6 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Molecular characterisation of cloned bradykinin B1 receptors from rat and human. Eur. J. Pharmacol. · 1999
- Structure and genomic organization of the human B1 receptor gene for kinins (BDKRB1). Genomics · 1996
- Genomic structure of the human bradykinin B1 receptor gene and preliminary characterization of its regulatory regions. Biochem. Biophys. Res. Commun. · 1996
- Expression cloning of a human B1 bradykinin receptor. J. Biol. Chem. · 1994
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