Adapter molecule crk

Function

Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.

Classification

Family (Pfam)

PF00017 SH2, PF00018 SH3_1, PF07653 SH3_2

InterPro

CRK_SH3_C, CRK_SH3_N, SH2, SH2_dom_sf, SH3-like_dom_sf, SH3_domain, Tyrosine-phos_adapter

Functional cluster

Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 10

• 1JU5 NMR
• 2DVJ NMR
• 2EYV NMR
• 2EYW NMR
• 2EYX NMR
• 2EYY NMR
• 2EYZ NMR
• 2MS4 NMR
• 5UL6 X-ray 1.45A
• 6ATV X-ray 1.75A

A predicted model is available from AlphaFold.

Gene Ontology · 52

• GO:0015629 actin cytoskeleton
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0031594 neuromuscular junction
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0032991 protein-containing complex
• GO:0008092 cytoskeletal protein binding
• GO:0005159 insulin-like growth factor receptor binding
• GO:0019900 kinase binding
• GO:0001784 phosphotyrosine residue binding
• GO:0045309 protein phosphorylated amino acid binding
• GO:1990782 protein tyrosine kinase binding
• GO:0030971 receptor tyrosine kinase binding
• GO:0097110 scaffold protein binding
• GO:0042169 SH2 domain binding
• GO:0017124 SH3 domain binding
• GO:0035591 signaling adaptor activity
• GO:0030159 signaling receptor complex adaptor activity
• GO:0031625 ubiquitin protein ligase binding
• GO:0030036 actin cytoskeleton organization
• GO:0016477 cell migration
• GO:0008283 cell population proliferation
• GO:1990859 cellular response to endothelin
• GO:1990314 cellular response to insulin-like growth factor stimulus
• GO:1990090 cellular response to nerve growth factor stimulus
• GO:0071732 cellular response to nitric oxide
• GO:0071560 cellular response to transforming growth factor beta stimulus
• GO:0007167 enzyme-linked receptor protein signaling pathway
• GO:0048013 ephrin receptor signaling pathway
• GO:2000146 negative regulation of cell motility
• GO:0045953 negative regulation of natural killer cell mediated cytotoxicity
• GO:0061045 negative regulation of wound healing
• GO:0030307 positive regulation of cell growth
• GO:0046330 positive regulation of JNK cascade
• GO:0035022 positive regulation of Rac protein signal transduction
• GO:0014911 positive regulation of smooth muscle cell migration
• GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
• GO:0098698 postsynaptic specialization assembly
• GO:0072657 protein localization to membrane
• GO:0032956 regulation of actin cytoskeleton organization
• GO:0008360 regulation of cell shape
• GO:1902531 regulation of intracellular signal transduction
• GO:0009966 regulation of signal transduction
• GO:0006357 regulation of transcription by RNA polymerase II
• GO:0061847 response to cholecystokinin
• GO:0035728 response to hepatocyte growth factor
• GO:0042542 response to hydrogen peroxide
• GO:1901652 response to peptide
• GO:0001878 response to yeast

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Adapter molecule crk 1.00
• Adapter molecule crk 1.00
• Adapter molecule crk 0.98
• Adapter molecule crk 0.95
• Crk-like protein 0.90
• Crk-like protein 0.89
• Crk-like protein 0.89
• GRB2-related adaptor protein 2 0.85
• Cell death abnormality protein 2 0.84
• Cell death abnormality protein 2 0.83
• GRB2-related adapter protein 2 0.81
• Growth factor receptor-bound protein 2-A 0.78

Co-cited proteins · studied together in the literature

• Protein PEAK3 1 shared papers
• Dedicator of cytokinesis protein 1 3 shared papers
• Dedicator of cytokinesis protein 4 1 shared papers
• Crk-like protein 2 shared papers
• SH2 domain-containing adapter protein B 1 shared papers
• Rap guanine nucleotide exchange factor 1 2 shared papers
• Breast cancer anti-estrogen resistance protein 1 3 shared papers
• Vascular endothelial growth factor receptor 3 1 shared papers
• Inactive tyrosine-protein kinase PEAK1 1 shared papers
• Platelet-derived growth factor receptor alpha 1 shared papers
• E3 ubiquitin-protein ligase CBL-C 1 shared papers
• Tyrosine-protein kinase ABL1 2 shared papers

Literature · 35 cited papers

• PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. Proc. Natl. Acad. Sci. U.S.A. · 2019
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
• System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. Proc. Natl. Acad. Sci. U.S.A. · 2010
• Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
• Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. BMC Immunol. · 2009
• Unc119 protects from Shigella infection by inhibiting the Abl family kinases. PLoS ONE · 2009
• DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. J. Biol. Chem. · 2009
• … and 23 more in the literature graph