Endothelin-converting enzyme 1

Function

Converts big endothelin-1 to endothelin-1.

Classification

Family (Pfam)

PF01431 Peptidase_M13, PF05649 Peptidase_M13_N

InterPro

MetalloPept_cat_dom_sf, Peptidase_M13, Peptidase_M13_C, Peptidase_M13_dom_2, Peptidase_M13_N

Functional cluster

Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 1

• 3DWB X-ray 2.38A

A predicted model is available from AlphaFold.

Gene Ontology · 34

• GO:0005769 early endosome
• GO:0005768 endosome
• GO:0010008 endosome membrane
• GO:0009897 external side of plasma membrane
• GO:0070062 extracellular exosome
• GO:0005765 lysosomal membrane
• GO:0016020 membrane
• GO:0048471 perinuclear region of cytoplasm
• GO:0005886 plasma membrane
• GO:0031982 vesicle
• GO:0033093 Weibel-Palade body
• GO:0004175 endopeptidase activity
• GO:0004222 metalloendopeptidase activity
• GO:0017046 peptide hormone binding
• GO:0042803 protein homodimerization activity
• GO:0008270 zinc ion binding
• GO:0060385 axonogenesis involved in innervation
• GO:0010815 bradykinin catabolic process
• GO:0010816 calcitonin catabolic process
• GO:0043583 ear development
• GO:0042733 embryonic digit morphogenesis
• GO:0035050 embryonic heart tube development
• GO:0034959 endothelin maturation
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007507 heart development
• GO:0042447 hormone catabolic process
• GO:0016486 peptide hormone processing
• GO:0001921 positive regulation of receptor recycling
• GO:0016485 protein processing
• GO:0003100 regulation of systemic arterial blood pressure by endothelin
• GO:0019229 regulation of vasoconstriction
• GO:0071526 semaphorin-plexin signaling pathway
• GO:0010814 substance P catabolic process
• GO:0097492 sympathetic neuron axon guidance

Disease associations

• Hirschsprung disease, cardiac defects, and autonomic dysfunction MONDO:0013473

Drugs targeting this protein · 1

• DAGLUTRIL inhibitor

Related proteins · sequence + function similarity

• Endothelin-converting enzyme 1 0.99
• Endothelin-converting enzyme 1 0.99
• Endothelin-converting enzyme 1 0.99
• Endothelin-converting enzyme 1 0.98
• Endothelin-converting enzyme 2 0.95
• Endothelin-converting enzyme 2 0.95
• Endothelin-converting enzyme homolog 0.94
• Membrane metallo-endopeptidase-like 1 0.93
• Endothelin-converting enzyme 2 0.93
• Neprilysin-2 0.92
• Membrane metallo-endopeptidase-like 1 0.91
• Membrane metallo-endopeptidase-like 1 0.91

Co-cited proteins · studied together in the literature

• Endothelin-converting enzyme 1 1 shared papers
• Endothelin-converting enzyme 1 1 shared papers
• Tetraspanin-8 1 shared papers
• Basic phospholipase A2 homolog 2 2 shared papers
• Neprilysin 2 shared papers
• Macrosialin 1 shared papers
• Sushi domain-containing protein 1 1 shared papers
• Beta-galactosidase 1 shared papers
• Platelet glycoprotein V 1 shared papers
• Lymphocyte antigen 6 complex locus protein G6f 1 shared papers
• Lysosomal protective protein 1 shared papers
• Multimerin-1 1 shared papers

Literature · 22 cited papers

• The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity. Cancers · 2023
• Corrigendum: N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin. Sci. Rep. · 2016
• N-terminal domain of Bothrops asper Myotoxin II enhances the activity of endothelin converting enzyme-1 and neprilysin. Sci. Rep. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
• Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat. Biotechnol. · 2009
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
• Structure of human endothelin-converting enzyme I complexed with phosphoramidon. J. Mol. Biol. · 2009
• A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell · 2006
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• … and 10 more in the literature graph