lmmol · Proteins

Isoleucine--tRNA ligase

UniProt P41972 Organism Staphylococcus aureus Gene ileS EC 6.1.1.5

Also known as: ileS

Function

Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity).

Classification

Family (Pfam)
PF08264 Anticodon_1, PF00133 tRNA-synt_1, PF06827 zf-FPG_IleRS
InterPro
aa-tRNA-synth_I_CS, aa-tRNA-synth_Ia, Anticodon_Ile_BEm, Ile-tRNA-ligase, Ile-tRNA-ligase_type1, Ile-tRNA_ligase, M/V/L/I-tRNA-synth_anticd-bd, Rossmann-like_a/b/a_fold, tRNAsynth_Ia_anticodon-bd, Val/Leu/Ile-tRNA-synth_edit, Znf_FPG/IleRS
Functional cluster
Aminoacyl-tRNA Synthetases

Experimental structures · PDB · 3

A predicted model is available from AlphaFold.

Gene Ontology · 7

Drugs targeting this protein · 2

Related proteins · sequence + function similarity

Literature · 2 cited papers

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