Prostaglandin-H2 D-isomerase

UniProt P41222 Organism Homo sapiens Gene PDS, PTGDS EC 5.3.99.2

Also known as: PDS, PTGDS

Function

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).

Classification

Family (Pfam): PF00061 Lipocalin
InterPro: Calycin, Lipocalin, Lipocalin_CS, Lipocln_cytosolic_FA-bd_dom
Functional cluster: Immunoglobulin & Immune-Response Proteins

Experimental structures · PDB · 17

2WWP X-ray 2.00A
3O19 X-ray 1.66A
3O22 X-ray 1.40A
3O2Y X-ray 1.70A
4IMN X-ray 2.09A
4IMO X-ray 1.88A
4ORR X-ray 1.40A
4ORS X-ray 1.40A
4ORU X-ray 1.55A
4ORW X-ray 1.66A
4ORX X-ray 1.60A
4ORY X-ray 1.80A
… and 5 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Drugs targeting this protein · 1

ANTRAFENINE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Prostaglandin-H2 D-isomerase 1 shared papers
Prostaglandin-H2 D-isomerase 1 shared papers
Prostaglandin-H2 D-isomerase 1 shared papers
Proline-rich transmembrane protein 3 1 shared papers
Seizure protein 6 homolog 1 shared papers
Beta-galactoside alpha-2,6-sialyltransferase 2 1 shared papers
Testican-1 1 shared papers
Neuroendocrine convertase 1 1 shared papers
SPARC-like protein 1 1 shared papers
Neurocan core protein 1 shared papers
VPS10 domain-containing receptor SorCS1 1 shared papers
Podocalyxin-like protein 2 1 shared papers

Literature · 30 cited papers

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. J. Proteome Res. · 2013
Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. Mol. Cell. Proteomics · 2012
Structure-function analysis of human l-prostaglandin D synthase bound with fatty acid molecules. FASEB J. · 2010
Enrichment of glycopeptides for glycan structure and attachment site identification. Nat. Methods · 2009
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol. Cell. Proteomics · 2009
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
DNA sequence and analysis of human chromosome 9. Nature · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Lipocalin-type prostaglandin D synthase in essential hypertension. Hypertension · 2002
… and 18 more in the literature graph

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