lmmol · Proteins

All-trans-retinol dehydrogenase [NAD(+)] ADH7

UniProt P40394 Organism Homo sapiens Gene ADH7 EC 1.1.1.105, 1.1.1.1, 1.1.1.66

Also known as: ADH7

Function

Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation.

Classification

Family (Pfam)
PF08240 ADH_N, PF00107 ADH_zinc_N
InterPro
ADH-like_C, ADH-like_N, ADH_Zn_CS, GroES-like_sf, NAD(P)-bd_dom_sf
Functional cluster
Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 3

A predicted model is available from AlphaFold.

Gene Ontology · 15

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 16 cited papers

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