Large ribosomal subunit protein eL22

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

Classification

Family (Pfam)

PF01776 Ribosomal_L22e

InterPro

Ribosomal_eL22, Ribosomal_eL22_sf

Functional cluster

Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 118

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 106 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0098978 glutamatergic synapse
• GO:0005634 nucleus
• GO:0098793 presynapse
• GO:1990904 ribonucleoprotein complex
• GO:0008201 heparin binding
• GO:0042802 identical protein binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0140236 translation at presynapse

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL22 1.00
• Large ribosomal subunit protein eL22 1.00
• Large ribosomal subunit protein eL22 1.00
• Large ribosomal subunit protein eL22 0.99
• Large ribosomal subunit protein eL22 0.99
• Large ribosomal subunit protein eL22 0.98
• Large ribosomal subunit protein eL22 0.97
• Large ribosomal subunit protein eL22 0.94
• Large ribosomal subunit protein eL22 0.94
• Ribosomal protein eL22-like 0.93
• Ribosomal protein eL22-like 1 0.93
• Ribosomal protein eL22-like 0.92

Co-cited proteins · studied together in the literature

• Large ribosomal subunit protein eL22 1 shared papers
• Large ribosomal subunit protein eL22 1 shared papers

Literature · 13 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The DNA sequence, annotation and analysis of human chromosome 3. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Proteomic characterization of the human centrosome by protein correlation profiling. Nature · 2003
• A novel heparin-binding protein, HBp15, is identified as mammalian ribosomal protein L22. Biochem. Biophys. Res. Commun. · 1994
• … and 1 more in the literature graph