Thyrotropin-releasing hormone receptor

Function

Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, TRH_rcpt_1

Functional cluster

Membrane Transporters & GPCRs

Experimental structures · PDB · 4

• 7WKD EM 3.01A
• 7X1T EM 3.26A
• 7X1U EM 3.19A
• 7XW9 EM 2.70A

A predicted model is available from AlphaFold.

Gene Ontology · 4

• GO:0005886 plasma membrane
• GO:0004997 thyrotropin-releasing hormone receptor activity
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway

Disease associations

• hypothyroidism, congenital, nongoitrous, 7 MONDO:0032819

Drugs targeting this protein · 3

• PROTIRELIN agonist
• TALTIRELIN agonist
• ROVATIRELIN agonist

Related proteins · sequence + function similarity

• Thyrotropin-releasing hormone receptor 1.00
• Thyrotropin-releasing hormone receptor 1.00
• Thyrotropin-releasing hormone receptor 1.00
• Thyrotropin-releasing hormone receptor 0.99
• Thyrotropin-releasing hormone receptor 0.99
• Neuropeptides capa receptor 0.87
• [Phe13]-bombesin receptor 0.86
• Neuromedin U receptor homolog nmur-2 0.84
• Bombesin receptor subtype-3 0.84
• Bombesin receptor subtype-3 0.84
• Bombesin receptor subtype-3 0.84
• Bombesin receptor subtype-3 0.84

Literature · 12 cited papers

• Central hypothyroidism due to a TRHR mutation causing impaired ligand affinity and transactivation of Gq. J. Clin. Endocrinol. Metab. · 2017
• A novel thyrotropin-releasing hormone receptor missense mutation (P81R) in central congenital hypothyroidism. J. Clin. Endocrinol. Metab. · 2016
• A family with complete resistance to thyrotropin-releasing hormone. N. Engl. J. Med. · 2009
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. J. Neurochem. · 1999
• A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. J. Clin. Endocrinol. Metab. · 1997
• A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. Endocrinology · 1996
• Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene. J. Biol. Chem. · 1996
• Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. Biochem. Biophys. Res. Commun. · 1993
• Molecular cloning of a functional human thyrotropin-releasing hormone receptor. Biochem. Biophys. Res. Commun. · 1993
• Cloning and functional characterisation of the human TRH receptor. Mol. Cell. Endocrinol. · 1993
• Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. Biochim. Biophys. Acta · 1994